Genetic testing

PREIMPLANTATION genetic testing on embryos (PGS, PGD)

Wish of every couple who turns to us for infertility treatment is to have a healthy child. The only method in IVF that can precisely distinguish between chromosomally normal and chromosomally abnormal embryos is Preimplantation genetic testing on embryos. Prior to embryo transfer, each embryo is chromosomally analysed and couple is informed which embryos genetically healthy and suitable for embryo transfer.

Genetic abnormalities are a frequent cause of early miscarriages in the first trimester of the pregnancy. Preimplantation diagnosis helps prevent these losses.

PGD

PGD preimplantation genetic diagnosis

It is indicated if one or both partners have a genetic disorder in the family. In the diagnostics, we focus on the chromosomes that carry information about the defect:

  • Single gene defects for which
  • Chromosomal abnormalities, including inversions, deletions, aneuploidy (an abnormal number of chromosomes), and translocations (where a piece of one chromosome either becomes attached to another chromosome or swaps places with a segment from another chromosome)

Indication:

  • History of Chromosomally Abnormal Child or Pregnancy
  • Family history of structural chromosomal condition
  • Family history of X-linked disease
  • Inherited genetic disorders

 

How does the PGD work?

  • We cultivate embryos 120 hours after fertilization to reach blastocyst stage
  • We gently perform embryo biopsy taking few cells from each blastocyst embryo for genetic analysis
  • Biopsied celles are sent to genetic laboratory for analysis, in the meantime, embryos are kept cryopreserved (frozen via vitrification)
  • After genetic report is received (4-5 weeks after the biopsy), if confirmed to have healthy embryos for transfer, patient receives protocol for frozen embryo transfer
  • Healthy embryo is thawed on the day of the transfer and transferred in prepared uterus

PGS

PGS preimplantation genetic screening

In PGS we screen all chromosomes and transfer only euploid embryos, with correct number of chromosomes. Aneuploid embryos (genetically abnormal with abnormal number of chromosomes) are discarded in agreement with the couple and genetic laboratory.

Indication:

  • Higher reproductive age (maternal age over 36 years)
  • Recurrent implantation failure (repeatedly failed IVF cycles)
  • Recurrent miscarriages
  • Severe male infertility factor

 

How does the PGS work?

  • We cultivate embryos 120 hours after fertilization to reach blastocyst stage
  • We gently perform embryo biopsy taking few cells from each blastocyst embryo for genetic analysis
  • Biopsied celles are sent to genetic laboratory for analysis, in the meantime, embryos are kept cryopreserved (frozen via vitrification)
  • After genetic report is received (4-5 weeks after the biopsy), if confirmed to have healthy embryos for transfer, patient receives protocol for frozen embryo transfer
  • Healthy embryo is thawed on the day of the transfer and transferred in prepared uterus

Trisomy test

Prenatal genetic testing during first pregnancy trimester (Trisomy Tests)

Gyncare, Member of Medirex Group offers a non-invasive, safe and painless way of obtaining important information about the health of an unborn baby based on a sample of maternal blood. TRISOMY test, TRISOMY test XY and TRISOMY test + are non-invasive prenatal screening tests designed to exclude selected foetal chromosomal abnormalities as early as in the first three months of pregnancy.

 

                                 

 

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